- 8/2025 Our cryo-EM structure of the membrane-bound tissue factor/factor VIIa complex with a
factor X mimetic is now published in Blood, revealing how the trimolecular complex that
triggers blood clotting in both normal hemostasis and many thrombotic diseases
assembles on a membrane surface. This structure now provides a clear mechanistic
explanation for more than 30 years’ worth of biochemical studies about tissue factor’s
substrate-binding “exosite.” It also reveals a novel, membrane-dependent allosteric
activation mechanism to explain the otherwise puzzling phenomenon of
encryption/decryption of cell-surface tissue factor. This study was a highly rewarding
collaboration between the labs of James Morrissey, Melanie Ohi, and Michael
Cianfrocco at the University of Michigan, and Emad Tajkhorshid’s group at the
University of Illinois.
- 2/2025 Our lab’s latest paper, “Membrane-bound model of the ternary complex between factor VIIa/tissue factor and factor X,” is featured on the cover of Blood Advances.
3/2024 NHLBI published a shout-out for our work collaborative work with the Kizhakkedathu lab on the neutralization of polyphosphate by MPI 8 - 1/2024 Congratulations to Josepha for receiving the Aminoff Endowment award from the UMich Biological Chemistry department!
- 9/2023 Congratulations to Josepha for receiving the Anthony and Lillian Lu Award from the UMich Biological Chemistry department!
- 5/2023 Josepha was awarded the JTH Editor’s award for her paper “Antithrombotic potential of a single-domain antibody enhancing the activated protein C-cofactor activity of protein S”
- 2/2023 Jim was selected as a finalist for Science2Startup and will be participating in the symposium in May
- 10/2022 Josepha received the 2022 Biological Sciences Thesis Prize from the National Academy of Pharmacy of France
- 3/2022 Fabienne defended her thesis and was awarded her PhD and is ready to start her job at ClearView Healthcare Partners
- 2/2022 Josepha joined the Morrissey Lab as a new post-doc
- 1/2022 Divyani defended her thesis and was awarded her PhD and is ready to start her job at Eli Lilly
- 12/2021 Divyani published a paper in the Journal of Thrombosis and Hemostasis (JTH)
- 2/2021 Yuqi defended her thesis and was awarded her PhD and is ready to start her job at AbbVie
- 11/2020: Yuqi was awarded the 2020 Lee Murphy Memorial Prize from the Department of Biological Chemistry
- 9/2020: Fabienne published a paper in the Journal of Thrombosis and Haemostasis (JTH)
- 8/2020: Patrick published a paper in the Journal of Thrombosis and Haemostasis (JTH)
- 8/2020: Katie published a paper in PLOS ONE
- 3/2020: Patrick received a one year T32 Boxer Training Program in Molecular and Translational Hematology Postdoctoral Fellowship with options to renew up to 3 years
- 12/2019: Fabienne received a two-year pre-doctoral fellowship from the American Heart Association (AHA)
- 8/2019: Yuqi published a paper in the Journal of Thrombosis and Haemostasis (JTH)
- 8/2019: Fabienne received an “Outstanding Talk” Award at the Biological Chemistry Retreat in Kalamazoo, MI
- 7/2019: Patrick and Fabienne were awarded “Top Poster” Winner at the ISTH Congress in Melbourne, Australia
- 7/2019: Fabienne gave an oral presentation at the ISTH Congress in Melbourne, Australia
- 4/2019: Katie received the EDGE Award from the Endowment for the Basic Sciences (EBS) in the Medical School. This award is given in recognition of outstanding research productivity and innovation over the past year.
- 4/2019: Fabienne received the “Anthony and Lillian Lu Award” from the Department of Biological Chemistry. This award is awarded annually to a graduate student on the basis of academic background, achievement in graduate research and potential as a scientist.
- 3/2019: Patrick and Fabienne received an “Early Career Travel Award” from the International Society on Thrombosis and Haemostasis (ISTH)
- 11/2018: Yuqi received a two-year pre-doctoral fellowship from the American Heart Association (AHA) 2