Publications from Jim Morrissey’s Lab, 2021-PRESENT
Papers are listed in reverse chronological order, with review articles grouped separately at the end. Clicking on the article’s title will take you to the PubMed entry, if available. The links to the right will take you to our earlier papers and to our issued US patents.
Click here for a listing of Morrissey lab publications for all years in PubMed
ORIGINAL RESEARCH ARTICLES:
- Muller MP, Mortenson A, Sedzro JC, Wen PC, Morrissey JH, Tajkhorshid E. Membrane-bound model of the ternary complex between factor VIIa/tissue factor and factor X. Blood Adv. 2025 Feb 25;9(4):729-740. doi: 10.1182/bloodadvances.2024014845. PubMed PMID: 39671302.
- Vappala S, Smith SA, Kizhakkedathu JN, Morrissey JH. Inhibitors of Polyphosphate and Neutrophil Extracellular Traps. Semin Thromb Hemost. 2024 Oct;50(7):970-977. doi: 10.1055/s-0043-1768936. Epub 2023 May 16. Review. PubMed PMID: 37192652; PubMed Central PMCID: PMC10651799.
- Sedzro JC, Smith SA, Scott A, Wang Y, Travers RJ, Hemp R, Morse CN, Morrissey JH. Antipolyphosphate monoclonal antibodies derived from autoimmune mice. Res Pract Thromb Haemost. 2024 Aug;8(6):102550. doi: 10.1016/j.rpth.2024.102550. eCollection 2024 Aug. PubMed PMID: 39309228; PubMed Central PMCID: PMC11414566.
- La CC, Smith SA, Kalathottukaren MT, Haynes CA, Morrissey JH, Kizhakkedathu JN. External Trigger Free Charge Switchable Cationic Ligands in the Design of Safe and Effective Universal Heparin Antidote. Adv Healthc Mater. 2024 Aug;13(20):e2400108. doi: 10.1002/adhm.202400108. Epub 2024 Apr 3. PubMed PMID: 38537246; PubMed Central PMCID: PMC11305972.
- Morrissey JH. HRG to the Rescue. Arterioscler Thromb Vasc Biol. 2024 Jul;44(7):1671-1673. doi: 10.1161/ATVBAHA.124.321178. Epub 2024 Jun 26. PubMed PMID: 38924441; PubMed Central PMCID: PMC11210687.
- MacArthur TA, Goswami J, Navarro SM, Vappala S, La CC, Yudin N, Zietlow J, Smith SA, Morrissey JH, Spears GM, Bailey KR, Dong JF, Kozar RA, Kizhakkedathu JN, Park MS. INHIBITORS OF INORGANIC POLYPHOSPHATE AND NUCLEIC ACIDS ATTENUATE IN VITRO THROMBIN GENERATION IN PLASMA FROM TRAUMA PATIENTS. Shock. 2024 Jun 1;61(6):848-854. doi: 10.1097/SHK.0000000000002362. Epub 2024 Mar 25. PubMed PMID: 38662595; PubMed Central PMCID: PMC11161192.
- Hajeyah AA, Protty MB, Paul D, Costa D, Omidvar N, Morgan B, Iwasaki Y, McGill B, Jenkins PV, Yousef Z, Allen-Redpath K, Soyama S, Choudhury A, Mitra R, Yaqoob P, Morrissey JH, Collins PW, O’Donnell VB. Phosphatidylthreonine is a procoagulant lipid detected in human blood and elevated in coronary artery disease. J Lipid Res. 2024 Jan;65(1):100484. doi: 10.1016/j.jlr.2023.100484. Epub 2023 Dec 14. PubMed PMID: 38103786; PubMed Central PMCID: PMC10809103.
- Cheng KJ, De Lio AM, Jain R, Paul D, Morrissey JH, Pogorelov TV. Lactadherin’s Multistate Binding Predicts Stable Membrane-Bound Conformations of Factors V and VIII’s C Domains. Biochemistry. 2023 Oct 17;62(20):3020-3032. doi: 10.1021/acs.biochem.3c00274. Epub 2023 Sep 25. PubMed PMID: 37747791; PubMed Central PMCID: PMC10903746.
- Shamanaev A, Litvak M, Cheng Q, Ponczek M, Dickeson SK, Smith SA, Morrissey JH, Gailani D. A site on factor XII required for productive interactions with polyphosphate. J Thromb Haemost. 2023 Jun;21(6):1567-1579. doi: 10.1016/j.jtha.2023.02.014. Epub 2023 Mar 1. PubMed PMID: 36863563; PubMed Central PMCID: PMC10192085.
- Sedzro JC, Smith SA, Scott A, Wang Y, Travers RJ, Hemp R, Morse CN, Morrissey JH. Antipolyphosphate monoclonal antibodies derived from autoimmune mice. Res Pract Thromb Haemost. 2024 Aug;8(6):102550. doi: 10.1016/j.rpth.2024.102550. eCollection 2024 Aug. PubMed PMID: 39309228; PubMed Central PMCID: PMC11414566.
- La CC, Smith SA, Kalathottukaren MT, Haynes CA, Morrissey JH, Kizhakkedathu JN. External Trigger Free Charge Switchable Cationic Ligands in the Design of Safe and Effective Universal Heparin Antidote. Adv Healthc Mater. 2024 Aug;13(20):e2400108. doi: 10.1002/adhm.202400108. Epub 2024 Apr 3. PubMed PMID: 38537246; PubMed Central PMCID: PMC11305972.
- Conway EM, Mackman N, Warren RQ, Wolberg AS, Mosnier LO, Campbell RA, Gralinski LE, Rondina MT, van de Veerdonk FL, Hoffmeister KM, Griffin JH, Nugent D, Moon K, Morrissey JH. Understanding COVID-19-associated coagulopathy. Nat Rev Immunol. 2022 Oct;22(10):639-649. doi: 10.1038/s41577-022-00762-9. Epub 2022 Aug 5. Review. PubMed PMID: 35931818; PubMed Central PMCID: PMC9362465.
- Goswami J, MacArthur TA, Mahony C, Kizhakkedathu JN, Vappala S, Smith S, Morrissey JH, Spears GM, Bailey KB, Dong J-F, Kozar RA, Hall N, Johnstone A, Park MS. DNAse mediated dissolution of neutrophil extracellular traps (NETs) accelerates in vitro thrombin generation kinetics in trauma patients. Shock 58:217–223, 2022.
- Muller MP, Morrissey JH, Tajkhorshid E. Molecular view into preferential binding of the factor VII GLA domain to phosphatidic acid. Biochemistry 61:1694–1703, 2022.
- Moore HB, Neal MD, Bertolet M, Joughin BA, Yaffe MB, Barrett CD, Bird MA, Tracy RP, Moore EE, Sperry JL, Zuckerbraun BS, Park MS, Cohen MJ, Wisniewski SR, Morrissey JH, TACTIC Investigators. Proteomics of coagulopathy following injury reveals limitations of using laboratory assessment to define trauma-induced coagulopathy to predict massive transfusion. Ann Surg Open 3:e167, 2022. PMCID: PMC9514137
- Abbina S, La CC, Vappala S, Kalathottukaren MT, Abbasi U, Gill A, Smith SA, Haynes CA, Morrissey JH, and Kizhakkedathu J. The influence of steric shield on biocompatibility and antithrombotic activity of dendritic polyphosphate inhibitor. Mol Pharm 19:1853-1865, 2022. PMCID: PMC9241529
- Paul D and Morrissey JH. Stoichiometric analysis reveals a unique phosphatidylserine binding site in coagulation factor X. J Thromb Haemost 20:600-604, 2022. PMCID: PMC8885840
- Wu J, Vodovotz Y, Abdelhamid S, Guyette FX, Yaffe MB, Gruen DS, Cyr A, Okonkwo DO, Kar UK, Krishnamoorthi N, Voinchet RG, Billiar IM, Yazer MH, Namas RA, Daley BJ, Miller RS, Harbrecht BG, Claridge JA, Phelan HA, Zuckerbraun BS, Johansson PI, Stensballe J, Morrissey JH, Tracy RP, Wisniewski SR, Neal MD, Sperry JL, Billiar TR, and PAMPer study group. Multi-omic analysis in injured humans: Patterns align with outcomes and treatment responses. Cell Rep Med 2:100478, 2021. PMCID: PMC8715070
- Shi H, Gandhi AA, Smith SA, Chiang D, Yalavarthi S, Ali RA, Liu C, Sule G, Tsou P-S, Zuo Y, Kanthi Y, Morrissey JH, and Knight JS. Endothelium-protective, histone-neutralizing properties of the polyanionic agent defibrotide. JCI Insight 6:149149, 2021. PMCID: PMC849231
- Sharma T, Brunet JG, Tasneem S, Smith SA, Morrissey JH, and Hayward CPM. Thrombin generation abnormalities in commonly encountered platelet function disorders. Int J Lab Hematol 43:1557-1565, 2021. PMCID: PMC8599625
- Birkle F and Morrissey JH. A serine loop in tissue factor mediates substrate selectivity by the tissue factor – factor VIIa complex. J Thromb Haemost 19:75-84, 2021. PMCID: PMC7790960
- ➞ Commentary: Schulman S. How the tissue factor-VIIa complex keeps two substrates in the loop. J Thromb Haemost. 19:52-54, 2021.