2011-2020

Publications from Jim Morrissey’s Lab, 2011-2022

Papers are listed in reverse chronological order, with review articles grouped separately at the end. Clicking on the article’s title will take you to the PubMed entry, if available. The links to the right will take you to our earlier papers and to our issued US patents.

Click here for a listing of Morrissey lab publications for all years in PubMed

ORIGINAL RESEARCH ARTICLES:

•  Zuo Y, Estes SK, Ali RA, Gandhi AA, Yalavarthi S, Shi H, Sule G, Gockman K, Madison JA, Zuo M, Yadav V, Wang J, Woodward W, Lezak SP, Lugogo NL, Smith SA, Morrissey JH, Kanthi Y, and Knight JS. Prothrombotic antiphospholipid antibodies in COVID-19. Sci Transl Med 12:eabd3876, 2020. PMCID: PMC7562748
  ➞ Highlighted as the cover illustration for the November 18, 2020 issue of Science Translational Medicine
  
• Medfisch SM, Muehl EM, Morrissey JH, and Bailey RC. Phosphatidylethanolamine-phosphatidylserine binding synergy of seven coagulation factors revealed using Nanodisc arrays on silicon photonic sensors. Sci Rep 10:17407, 2020. PMCID: PMC7562748
• Suess PM, Smith SA, and Morrissey JH. Platelet polyphosphate induces fibroblast chemotaxis and myofibroblast differentiation. J Thromb Haemost 18:3043-3052, 2020.
• Baker CJ, Smith SA, and Morrissey JH. Diversification of polyphosphate end-labeling via bridging molecules. PLoS ONE 15:e0237849, 2020. PMCID: PMC7446893
• Roewe J, Stavrides G, Strueve M, Sharma A, Marini F, Mann A, Smith SA, Kaya Z, Strobl B, Mueller M, Reinhardt C, Morrissey JH, and Bosmann M. Bacterial polyphosphates interfere with the innate host defense to infection. Nat Commun 11:4035, 2020. PMCID: PMC7423913
• Christ JJ, Smith SA, Willbold S, Morrissey JH, and Blank LM. Biotechnological synthesis of water-soluble food-grade polyphosphate with Saccharomyces cerevisiae. Biotechnol Bioeng 117:2089-2099, 2020. PMCID: PMC7375355
• Lin BH, Sutherland MR, Rosell FI, Morrissey JH, and Pryzdial ELG. Coagulation factor VIIa binds to herpes simplex virus 1‐encoded glycoprotein C forming a factor X‐enhanced tenase complex oriented on membranes. J Thromb Haemost 18:1370-1380, 2020.
• Wang Y, Ivanov I, Smith SA, Gailani D, Morrissey JH. Polyphosphate, Zn²⁺ and high molecular weight kininogen modulate individual reactions of the contact pathway of blood clotting. J Thromb Haemost. 2019; 17: 2131-40.
• Zilberman-Rudenko J, Reitsma SE, Puy C, Rigg RA, Smith SA, Tucker EI, Silasi R, Merkulova A, McCrae KR, Maas C, Urbanus RT, Gailani D, Morrissey JH, Gruber A, Lupu F, Schmaier AH, and McCarty OJ. Factor XII activation promotes platelet consumption in the presence of bacterial-type long-chain polyphosphate in vitro and in vivo. Arterioscler Thromb & Vasc Biol 38:1748-1760, 2018. PMCID: PMC6205188
• Hallock MJ, Alexander I Greenwood AI, Wang Y, Morrissey JH, Tajkhorshid E., Rienstra CM, and Pogorelov TV. Calcium-induced lipid nanocluster structures: sculpturing of the plasma membrane. Biochemistry 57:6897–6905, 2018. PMCID: PMC6475452
• Negreiros RS, Lander N, Huang G, Cordeiro CD, Smith SA, Morrissey JH, Docampo R. Inorganic polyphosphate interacts with nucleolar and glycosomal proteins in trypanosomatids. Mol Microbiol. 2018; 110: 973-94.
• Smith SA, Wang Y, Morrissey JH. DNA ladders can be used to size polyphosphate resolved by polyacrylamide gel electrophoresis. Electrophoresis. 2018; 39: 2454-59.
• Smith SA, Gajsiewicz JM, and Morrissey JH. Ability of polyphosphate and nucleic acids to trigger blood clotting: Some observations and caveats. Front Med 5:107, 2018. PMCID: PMC5913279
• Slatter DA, Percy CL, Allen-Redpath K, Gajsiewicz JM, Brooks NJ, Clayton A, Tyrrell VJ, Rosas M, Lauder SN, Watson A, Dul M, Garcia-Diaz Y, Aldrovandi M, Heurich M, Hall J, Morrissey JH, Lacroix-Desmazes S, Delignat S, Vincent Jenkins P, Collins PW & O’Donnell VB. Enzymatically oxidized phospholipids restore thrombin generation in coagulation factor deficiencies. JCI Insight 3:e98459, 2018. PMCID: PMC5926910
• Mafi A, Abbina S, Kalathottukaren MT, Morrissey JH, Haynes C, Kizhakkedathu JN, Pfaendtner J, Chou KC. Design of polyphosphate inhibitors: A molecular dynamics investigation on polyethylene-glycol-linked cationic binding groups. Biomacromolecules 19:1358-1367, 2018.
• Muehl EM, Gajsiewicz JM, Medfisch SM, Wiersma ZSB, Morrissey JH, and Bailey RC. Multiplexed silicon photonic sensor arrays enable facile characterization of coagulation protein binding to Nanodiscs with variable lipid content. J Biol Chem 292:16249-16256, 2017. PMCID: PMC5625054
• Muller MP Wang Y, Morrissey JH, and Tajkhorshid E. Lipid specificity of the membrane binding domain of coagulation factor X. J Thromb Haemost 15:2005-2016, 2017. PMCID: PMC5630516
• Smith SA, Baker CJ, Gajsiewicz JM, and Morrissey JH. Silica particles contribute to the procoagulant activity of DNA and polyphosphate isolated using commercial kits. Blood 130:88-91, 2017. PMCID: PMC5501151
• Yeon JH, Nima Mazinani N, Schlappi TS, Chan KYT, Baylis JR, Smith SA, Donovan AJ, Kudela D, Stucky GD, Liu L, Morrissey JH, and Kastrup CJ. Localization of short-chain polyphosphate enhances its ability to clot flowing blood plasma. Sci Rep 7:42119, 2017. PMCID: PMC5301195
• Kalathottukaren MT, Abraham L, Kapopara PR, Lai BF, Shenoi RA, Rosell FI, Conway EM, Pryzdial EL, Morrissey JH, Haynes CA, and Kizhakkedathu JN. Alteration of blood clotting and lung damage by protamine are avoided using the heparin and polyphosphate inhibitor UHRA. Blood 129:1368-1379, 2017. PMCID: PMC5345737
• Gajsiewicz JM, Smith SA, and Morrissey JH. Polyphosphate and RNA differentially modulate the contact pathway of blood clotting. J Biol Chem 292:1808-1814, 2017. PMCID: PMC5290954
• Sylman JL, Daalkhaijav U, Zhang Y, Gray EM, Farhang P, Chu TT, Zilberman-Rudenko J, Puy C, Tucker EI, Smith SA, Morrissey JH, Walker TW, Nan XL, Gruber A, and McCarty OJT. Differential roles for the coagulation factors XI and XII in regulating the physical biology of fibrin. Ann Biomed Eng 45:1328-1340, 2017. PMCID: PMC5398924
• Cines DB, Yarovoi SV, Zaitsev SV, Lebedeva T, Rauova L, Poncz M, Arepally GM, Khandelwal S, Stepanova V, Rux AH, Cuker A, Guo C, Ocariza LM, Travers RJ, Smith SA, Kim H, Morrissey JH and Conway EM. Polyphosphate/platelet factor 4 complexes can mediate heparin-independent platelet activation in heparin-induced thrombocytopenia. Blood Adv 1:62-74, 2016.
• Puy C, Tucker EI, Ivanov IS, Gailani D, Smith SA, Morrissey JH, Gruber A, and McCarty OJ. Platelet-derived short-chain polyphosphates enhance the inactivation of tissue factor pathway inhibitor by activated coagulation factor XI. PLoS One 11:e0165172, 2016. PMCID: PMC5072614
• Nuzzio KM, Watt ED, Boettcher JM, Gajsiewicz JM, Morrissey JH, and Rienstra CM. High-resolution NMR studies of human tissue factor. PLoS One 11:e0163206, 2016. PMCID: PMC5033421
• Donovan AJ, Kalkowski J, Szymusiak M, Wang C, Smith SA, Klie RF, Morrissey JH, and Liu Y. Artificial dense granules: A procoagulant liposomal formulation modeled after platelet polyphosphate storage pools. Biomacromolecules 17:2572-2581, 2016. PMC Journal
• Wijeyewickrema LC, Lameignere E, Hor l, Duncan RC, Shiba T, Travers RJ, Kapopara PR, Lei V, Smith SA, Kim H, Morrissey JH, Pike RN and Conway EM. Polyphosphate is a novel cofactor for regulation of complement by the serpin, C1-inhibitor. Blood 128:1766-1776, 2016. PMC Journal
• Szymusiak M, Donovan AJ, Smith SA, Ransom R, Shen H, Kalkowski J, Morrissey JH, and Liu Y. Colloidal confinement of polyphosphate on gold nanoparticles robustly activates the contact pathway of blood coagulation. Bioconjug Chem 27:102-109, 2016. PMC Journal
• Courtney JM, Ye Q, Nesbitt AE, Tang M, Tuttle MD, Watt ED, Nuzzio KM, Sperling LJ, Comellas G, Peterson JR, Morrissey JH, and Rienstra CM. Experimental protein structure verification by scoring with a single, unassigned NMR spectrum. Structure 23:1958-1966, 2015. PMCID: PMC4786943
• Gajsiewicz JM, Nuzzio KM, Rienstra CM, and Morrissey JH. Tissue factor residues that modulate magnesium-dependent rate enhancements of the tissue factor/factor VIIa complex. Biochemistry 54:4665-4771, 2015. PMCID: PMC4862878
• Zhu S, Travers RJ, Morrissey JH, and Diamond SL. FXIa and platelet polyphosphate as therapeutic targets during human blood clotting on collagen/tissue factor surfaces under flow. Blood 126:1494-1502, 2015. PMCID: PMC4573872
• Kudela D, Smith SA, May-Masnou A, Braun GB, Pallaoro A, Nguyen CK, Chuong TT, Nownes S, Allen R, Parker NR, Rashidi HH, Morrissey JH, and Stucky GD. Clotting activity of polyphosphate-functionalized silica nanoparticles. Angew Chem Int Ed Engl 54:4018-4022, 2015. PMCID: PMC4782980
• Choi SH, Smith SA, and Morrissey JH. Polyphosphate accelerates factor V activation by factor XIa. Thromb Haemost 113:599-604, 2015. PMCID: PMC4541292
• Donovan AJ, Kalkowski J, Smith SA, Morrissey JH, and Liu Y. Size-controlled synthesis of granular polyphosphate nanoparticles at physiologic salt concentrations for blood clotting. Biomacromolecules 15:3976-3984, 2014. PMC Journal
• Shenoi RA, Kalathottukaren MT, Travers RJ, Lai BFL, Creagh AL, Lange D, Yu K, Weinhart M, Chew BH, Du C, Brooks DE, Carter CJ, Morrissey JH, Haynes CA, and Kizhakkedathu JN. Affinity-based design of a synthetic universal reversal agent for heparin anticoagulants. Sci Transl Med 6:260ra150, 2014. PMC Journal
• Travers RJ, Shenoi RA, Kalathottukaren MT, Kizhakkedathu JN, and Morrissey JH. Nontoxic polyphosphate inhibitors reduce thrombosis while sparing hemostasis. Blood 124:3183-3190, 2014. PMCID: PMC4239329
• Hebbard CF, Wang Y, Baker CJ, and Morrissey JH. Synthesis and evaluation of chromogenic and fluorogenic substrates for high-throughput detection of enzymes that hydrolyze inorganic polyphosphate. Biomacromolecules 15:3190-6, 2014.
• Ke K, Yuan J, and Morrissey JH. Tissue factor residues that putatively interact with membrane phospholipids. PLoS ONE 9:e88675, 2014.
• Matafonov A, Leung PY, Gailani AE, Grach SL, Puy CG, Cheng Q, Sun M-f, McCarty OJT, Tucker EI, Kataoka H, Renné T, Morrissey JH, Gruber A, and Gailani D. Factor XII inhibition reduces thrombus formation in a primate thrombosis model. Blood 123:1739-46, 2014.
• Wat JM, Foley JH, Krisinger MJ, Ocariza LM, Lei V, Wasney GA, Lameignere E, Strynadka NC, Smith SA, Morrissey JH, and Conway EM. Polyphosphate suppresses complement via the terminal pathway. Blood 123:768-776, 2014.
  • Rated “Recommended” by the Faculty of 1000 Biology.
• Tavoosi N and Morrissey JH. Influence of membrane composition on the enhancement of factor VIIa/tissue factor activity by magnesium ions. Thromb Haemost 111:770-772, 2014.
• Geng Y, Verhamme IM, Smith SA, Cheng Q, Sun M-f, Sheehan JP, Morrissey JH and Gailani D. Factor XI anion-binding sites are required for productive interactions with polyphosphate. J Thromb Haemost 11:2020-2028, 2013.
• Tavoosi N, Smith SA, Davis-Harrison RL, and Morrissey JH. Factor VII and protein C are phosphatidic acid-binding proteins. Biochemistry 52:5545-5552, 2013.
• Puy C, Tucker EI, Wong ZC, Gailani D, Smith SA, Choi SH, Morrissey JH, Gruber A, and McCarty OJ. Factor XII promotes blood coagulation independent of factor XI in the presence of long chain polyphosphate. J Thromb Haemost 11:1341-1352, 2013.
• Geng Y, Verhamme I, Smith SB, Sun MF, Matafonov A, Cheng Q, Smith SA, Morrissey JH, and Gailani D. The dimeric structure of factor XI and zymogen activation. Blood 121:3962-3969, 2013.
• Smith SA, Choi SH, Collins JNR, Travers RJ, Cooley BC, and Morrissey JH. Inhibition of polyphosphate as a novel strategy for preventing thrombosis and inflammation. Blood 120:5103-5110, 2012.
  • Designated the “Plenary Paper” for the December 20, 2012 issue of Blood.
• Mutch NJ, Waters EK, and Morrissey JH. Immobilized transition metals stimulate contact activation and drive factor XII-mediated coagulation. J Thromb Haemost 10:2108-2115, 2012.
• Silveira A, Scanavini D, Boquist S, Ericsson CG, Hellénius ML, Leander K, de Faire U, Ohrvik J, Woodhams B, Morrissey JH, Hamsten A. Relationships of plasma factor VIIa-antithrombin complexes to manifest and future cardiovascular disease. Thromb Res, 130:221-225, 2012.
  • Commentary in Thromb. Res.
• Choi SH, Smith SA, Morrissey JH. Polyphosphate is a cofactor for the activation of factor XI by thrombin. Blood,118:6963-6970, 2011.
  • Commentary in the “Inside Blood” section of Blood
• Semeraro F, Ammollo CT, Morrissey JH, Dale GL, Friese P, Esmon NL, and Esmon, CT. Extracellular histones promote thrombin generation through platelet-dependent mechanisms: Involvement of platelet TLR2 and 4. Blood 118:1952-1961, 2011.
  • Commentary in the “Inside Blood” section of Blood
• Tavoosi N, Davis-Harrison RL, Pogorelov TV, Ohkubo YZ, Arcario MJ, Clay MC, Rienstra MC, Tajkhorshid E, and Morrissey JH. Molecular determinants of phospholipid synergy in blood clotting. J Biol Chem 285:23247-23253, 2011.
  • Highlighted on the cover of the Journal of Biological Chemistry
• Boettcher JM, Davis-Harrison RL, Clay MC, Nieuwkoop AJ, Ohkubo YZ, Tajkhorshid E, Morrissey JH, and Rienstra CM. Atomic view of calcium-induced clustering of phosphatidylserine in mixed lipid bilayers. Biochemistry 50:2264-2273, 2011.

REVIEW ARTICLES:

• Smith SA and Morrissey JH. Polyphosphate: a new player in the field of hemostasis. Curr Opin Hematol 21:388-94, 2014.
• Morrissey JH. Contributions of platelet polyphosphate to hemostasis and thrombosis. In: Hemostasis and Thrombosis: Practical Guidelines in Clinical Management, chapter 17, H Saba and H Roberts, eds. (Wiley-Blackwell, Oxford), pp. 236-245, 2014.
• Morrissey JH. One inositol ring to rule thrombosis. Blood 122:1331-1332, 2013.
• Morrissey JH. Targeting factor XI to prevent thrombosis. Arterioscler. Thromb. Vasc. Biol. 33:1454-1455, 2013.
• Morrissey JH. Coagulation factor VIIa. In: Handbook of Proteolytic Enzymes (Third Edition), chapter 641, ND Rawlings and G Salvesen, eds. (Academic Press/Elsevier, Oxford), pp. 2905-2908, 2013. Available electronically
• Morrissey JH and Broze, JG, Jr. Tissue factor and the initiation and regulation (TFPI) of coagulation. In: Hemostasis and Thrombosis: Basic Principles and Clinical Practice (Sixth Edition), chapter 11, VJ Marder, WC Aird, JS Bennett, S Schulman and GC White, eds. (Lippincott Williams & Wilkins, Philadelphia), pp. 163-178, 2013. R46.
• Morrissey JH. Polyphosphate multi-tasks. J Thromb Haemost 10:2313-2314, 2012.
• Morrissey JH. The many domains of TFPI. Thromb Haemost 108:206, 2012.
• Morrissey JH, Choi SH, and Smith S.A. Polyphosphate: an ancient molecule that links platelets, coagulation and inflammation. Blood 119:5972-5979, 2012.
• Morrissey JH, Tajkhorshid E, Sligar SG, and Rienstra CM. Tissue factor/factor VIIa complex: Role of the membrane surface. Thromb Res 129 (Suppl 2):S8-S10, 2012.
• Morrissey JH. Polyphosphate: a link between platelets, coagulation and inflammation. Int J Hematol 95:346-352, 2012.
• Morrissey JH. Low-carb tissue factor? J Thromb Haemost. 9:1508-1510, 2011.
• Morrissey JH, Tajkhorshid E, Rienstra CM. Nanoscale studies of protein-membrane interactions in blood clotting. J. Thromb Haemost. 9 Suppl 1:162-167, 2011.
• Morrissey JH. Taking the brakes off? Blood.117:3939-3940, 2011.