Morrissey Lab, University of Michigan

Jim Morrissey’s CV

James H. Morrissey, Ph.D.

WORK ADDRESS:

Depts. of Biological Chemistry & Internal Medicine
University of Michigan Med. School
4301B MSRB III
1150 West Medical Center Dr.
Ann Arbor, MI 48109, USA
Office: +1 734-763-3991
jim@tf7.org

EDUCATION:

RESEARCH EXPERIENCE/POSTDOCTORAL TRAINING:

  • 1973-1975, Combined B.S.-M.S. Program, Development Biology Department, University of California, Irvine; Irvine, CA (advisor: Gerald Greenhouse, Ph.D.)
  • 1975-1976, Graduate Student, Biology Department, Massachusetts Institute of Technology; Cambridge, MA (advisor: Howard Green, M.D.)
  • 1977-1980, Graduate Student, Biology Department, University of California, San Diego; La Jolla, CA (advisor: William Loomis, Ph.D.)
  • 1980-1981, Postdoctoral Fellow, Biology Department, University of California, San Diego; La Jolla, CA (advisor: William Loomis, Ph.D.)
  • 1982-1983, Postdoctoral Fellow, Biochemistry Department, University of Oxford; Oxford, UK (advisor: Peter Newell, D.Phil.)
  • 1983-1984, Senior Postdoctoral Fellow, Immunology Department, The Scripps Research Institute; La Jolla, CA (advisor: Thomas Edgington, M.D.)

FACULTY POSITIONS:

  • 1984-1989, Assistant Member, Immunology Department, The Scripps Research Institute; La Jolla, CA
  • 1989-1995, Associate Member,Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation (OMRF); Oklahoma City, OK
  • 1991-1997, OMRF Associate Professor of Pathology, University of Oklahoma Health Sciences Center (OUHSC); Oklahoma City, OK
  • 1995-2000, Member, Cardiovascular Biology Research Program, OMRF; Oklahoma City, OK
  • 1997-2000, OMRF Professor of Pathology, OUHSC; Oklahoma City, OK
  • 2000-2012, Professor of Medical Biochemistry, University of Illinois College of Medicine at Urbana-Champaign (UIUC), Urbana, IL
  • 2000-2017, Professor of Biochemistry, University of Illinois, Urbana, IL
  • 2012-2017, Roy & Eva Hong Professor of Molecular & Cellular Biology, University of Illinois, Urbana, IL
  • 2013-2014, Acting Head, Biochemistry Department, University of Illinois, Urbana IL
  • 2017, Professor, Carle Illinois College of Medicine, Urbana, IL
  • 2017-pres., Professor, Departments of Biological Chemistry and Internal Medicine, University of Michigan Medical School, Ann Arbor, MI

RESEARCH INTERESTS:

We are investigating how the blood clotting cascade is regulated, with applications to thrombotic diseases, bleeding disorders, and inflammation. Many of our studies have focused on understanding the initiation phase of blood clotting, an event that takes place when the soluble plasma protein, factor VIIa (a serine protease), binds to the integral membrane protein, tissue factor (TF), on cell surfaces. In 2006, we discovered that polyphosphate (an inorganic polymer of phosphate present in many infectious microorganism and secreted by activated human platelets) is a novel modulator of the blood clotting cascade and may represent the long-sought (patho)physiologic activator of the contact pathway of blood coagulation.

Our current research efforts focus primarily on: (1) Understanding, with atomic-scale resolution, how blood clotting proteins interact with membrane surfaces and how these membrane binding events contribute so profoundly to catalysis; (2) Understanding the mechanisms by which polyphosphate modulates the clotting system in hemostasis, thrombosis and inflammation; and (3) Developing a new toolkit of methods to solve, at atomic resolution, the structure and dynamics of membrane lipids as they interact with membrane proteins and other biologically important ligands.

CURRENT GRANT SUPPORT:

  • “Mechanisms in Blood Clotting” NIH (NHLBI) grant R35 HL135823. 01/15/2017 – 02/29/2024. Principal Investigator: J.H. Morrissey. (NHLBI Outstanding Investigator Award)
  • “Toolkit for High-Resolution Structure and Dynamics of Functional Lipids” NIH grant R01 GM123455. Principal Investigators: C.M. Rienstra (contact), J.H. Morrissey and E. Tajkhorshid. (High-Risk, High-Reward Research program from the NIH Common Fund)
  • “Analysis and Characterization of Trauma-Induced Coagulopathy” NIH (NHLBI) grant UM1 HL120877. 9/30/2013 – 5/31/2019. Principal Investigators: J.H. Morrissey (contact) & S. Wisnieski.
  • “Multiplexed Platform to Probe Interactions at the Model Cell Membrane Interface” NIH (NIGMS) grant R01GM110432. 4/2/2014 – 3/31/19. Principal Investigator: R. Bailey (my role: co-investigator).

HONORS, FELLOWSHIPS, AWARDS & NAMED LECTURES:

  • 1981, Young Investigator Award, Society for Developmental Biology
  • 1982-1983, Research Grant, Burroughs-Wellcome Fund (USA)
  • 1982-1983, EMBO Long Term Fellowship
  • 1983, Postdoctoral Fellowship, E.P. Abraham Research Fund
  • 1982-1983, Junior Research Fellowship (nonstipendiary), Wolfson College, Oxford
  • 1988-1993, Established Investigatorship, American Heart Association
  • 1991, The Owren Lecture, University of Oslo, Norway
  • 1992-2000, Fred Jones Distinguished Research Scientist, OMRF
  • 1994, Thelma and Edward L. Gaylord Award for Scientific Excellence, OMRF
  • 2006,Theodore Spaet Memorial Lecture, Montefiore Medical Center, Albert Einstein College of Medicine
  • 2007, Alumni Discretionary Award, College of Liberal Arts & Sciences, UIUC
  • 2011, Biennial Investigator Recognition Award for Contributions to Haemostasis; awarded in Kyoto, Japan, at the XXIIIrd Congress of the International Society on Thrombosis & Haemostasis (ISTH)
  • 2012, Roy & Eva Hong Professorship in Molecular & Cellular Biology (also listed above under faculty positions)
  • 2013, Sol Sherry Distinguished Lecture in Thrombosis; given at Scientific Sessions 2013, American Heart Association
  • 2014, Outstanding Advisor of the Year Award, from the Medical Scholars Program, UIUC

TEACHING AWARDS & RECOGNITION

  • 2007, Listed in “Teachers Ranked as Excellent by Their Students,” by the UIUC Center for Teaching Excellence, for my teaching in Medical Biochemistry (BMS602/613)
  • 2008, Listed in “Teachers Ranked as Excellent by Their Students” for my teaching in Medical Biochemistry (BMS602/613) and in Current Topics in Biochemistry (BIOC 445)
  • 2009, Listed in “Teachers Ranked as Excellent by Their Students” for my teaching in Medical Biochemistry (BMS602/613) and in Current Topics in Biochemistry (BIOC 445)
  • 2010 Listed (and ranked “outstanding”) in “Teachers Ranked as Excellent by Their Students” for my teaching in Medical Biochemistry I & II (BMS602/613)
  • 2011 Listed in “Teachers Ranked as Excellent by Their Students” for my teaching in Medical Biochemistry I & II (BMS602/613)
  • Ranked “outstanding” in “Teachers Ranked as Excellent by Their Students” for my teaching in Medical Biochemistry I & II (BMS602/613)
  • 2013 Ranked “outstanding” in “Teachers Ranked as Excellent by Their Students” for MCB 297 (the Honors Discussion section of Biochemical & Physical Basis of Life)
  • 2014 Listed in “Teachers Ranked as Excellent by Their Students” at UIUC for BIOC 555A (Analysis of Biochemical Literature)

PROFESSIONAL AFFILIATIONS:

  • 1987-present, Member, International Society of Thrombosis and Hemostasis (ISTH)
  • 1993-present, Member, American Society of Hematology (ASH)
  • 1998-present, Member, American Society for Biochemistry and Molecular Biology (ASBMB)
  • 2011-present, Member, American Chemical Society (ACS)
  • 2018-present, American Association for the Advancement of Science (AAAS)

ADVISORY COMMITTEES AND OTHER SERVICE (Regional, National & International):

  • 1993-1996, Member, Program Committee, AHA Council on Thrombosis
  • 1994-1996, Member, Nominating Committee, AHA Council on Thrombosis
  • 1995-1996, Leader, Tissue Factor Working Group, 6th International Workshop & Conference on Human Leukocyte Differentiation Antigens
  • 1994-1998, Member, Board of Directors, AHA Oklahoma Affiliate
  • 1994-1995, Vice President for Research, AHA Oklahoma Affiliate
  • 1996-1997, President, AHA Oklahoma Affiliate
  • 1997-1998, Vice President of Public Affairs, AHA Oklahoma Affiliate
  • 1998, Member, Board of Directors, AHA Heartland Affiliate
  • 1997-2000, Chair, Endothelial Section, 7th International Workshop & Conference on Human Leucocyte Differentiation Antigens (HLDA7)
  • 2000-2003 Member, Executive Committee, AHA Council on Arteriosclerosis, Thrombosis and Vascular Biology
  • 2001, Invited participant, CNS Thrombosis and Hemorrhage Section of the Stroke Progress Review Group for the National Institute of Neurological Disorders and Stroke (NINDS)
  • 2001-2002, Senior Vice Chair, Program Committee, AHA Council on Arteriosclerosis, Thrombosis and Vascular Biology
  • 2004-2009, Member, External Advisory Board, NIH COBRE grant at the Oklahoma Medical Research Foundation
  • 2005, Invited participant, NIH (NINDS/CSN/NHLBI) Workshop on Immunomodulation Strategies for Preventing Vascular Disease of the Brain and Heart
  • 2006, Invited participant, Hemostasis/Endothelium Section of the Stroke Progress Review Group for the National Institute of Neurological Disorders and Stroke (NINDS)
  • 2007-2008 Co-organizer (with Nigel Mackman), 4th Symposium on Hemostasis with Special Focus on Factor VIIa and Tissue Factor, Chapel Hill, NC, April 3-5, 2008
  • 2008-2010, ASH Scientific Committee on Hemostasis (Vice-Chair 2008-2009; Chair 2009-2010)
  • 2004-2012, Director, Cell & Molecular Biology Training Grant at the University of Illinois at Urbana-Champagin (funded by NIH)
  • 2012-pres., Member, ISTH Council (the board of directors of this society; my term expires in 2018)
  • 2012-pres., Chair, ISTH Lectures & Awards Committee
  • 2012-pres., Member, ISTH Publications Committee
  • 2103-2017, Co-Chair, ISTH/SSC Subcommittee on Factor XI and the Contact System
  • 2014, Vice-chair (with Jorge DiPaola), Gordon Research Conference on Hemostasis
  • 2014-present, Chair, ISTH Ethics Committee
  • 2015-2016, Member, ISTH Task Force on Open-Access Publishing
  • 2016-present, Member, ISTH Basic and Clinical Research Task Force
  • 2016, Chair (with Jorge DiPaola), Gordon Research Conference on Hemostasis

GRANT REVIEW :

  • NIH Study Sections:
    • Hematology-1 (ad hoc, 1993, 1994, 2000)
    • Hemostasis & Thrombosis (ad hoc, 2004, 2009)
    • NIH Program Project Grant Review (ad hoc many years; most recently, 2006)
    • NIH Special Emphasis Panels (ad hoc, 1998, 2000, 2002, 2003, 2005).
    • NIH Hemostasis & Thrombosis (HT) Study Section: member, 2011-2017; chair, 2013-2015.
    • NIH Special Emphasis Panel (mail reviewer) for Director’s Pioneer Award Program: 2018
    • NIH Special Emphasis Panel ZRG1 VH-D (Platelets & Thrombosis): 2018
  • National Science Foundation (ad hoc 2004)
  • Medical Research Council, UK (ad hoc 1993)
  • VA Medical Research Service (ad hoc, several years; most recently, 2002)
  • AHA (National) Thrombosis Study Group (member, 1996-99 & 2002; chair, 2003-04)
  • Fondazione Telethon, Italy (ad hoc 2001, 2002, 2003, 2005, 2006)
  • Canadian Blood Services Intramural Grants Competition (ad hoc 2002, 2003, 2005)
  • Clive & Vera Ramaciotti Foundation, Australia (ad hoc 2002)
  • Wellcome Trust, UK (ad hoc 2008, 2009)
  • Diabetes UK (ad hoc 2009, 2010)
  • Research Grants Council (RGC) of Hong Kong (ad hoc): 2011, 2012
  • Michael Smith Foundation for Health Research, British Columbia, Canada (ad hoc): 2012
  • Austrian Science Fund (FWF) (ad hoc): 2013
  • Welsh Government’s Sêr Cymru II Precision Medicine Programme (ad hoc): 2018

EDITORIAL BOARDS:

  • Arteriosclerosis, Thrombosis & Vascular Biology (Editorial Board, 2007-2012)
  • Blood (Editorial Board, 1996-2000)
  • Endothelium (Editorial Board, 1999-2008)
  • Journal of Biological Chemistry (Editorial Board, 1997-2002 & 2003-2008)
  • Journal of Thrombosis & Haemostasis (Editorial Advisory Board, 2005-2012)
  • Thrombosis & Haemostasis (Section Editor, 2008-2013.)
  • TRIGGER (Founder & Editor, electronic newsletter on Tissue Factor, Factor VII & TFPI, 1995-pres.)
  • Journal of Clinical Investigation (member, board of consulting editors, 2012-present)
  • Journal of Thrombosis and Haemostasis (Associate Editor, 2016-present)
  • Journal of Thrombosis and Haemostasis (Editor-in-Chief, jointly with Dr. David Lillicrap, starting January 2019)