Curriculum Vitae
James H. Morrissey, Ph.D.

 

Publications, 1974 to 1985

Publications, 1986 to 1994

Publications, 1995 to 1999

Publications, 2000 to present

Brief CV from the University of Illinois web site
WORK ADDRESS:

Department of Biochemistry
College of Medicine
University of Illinois at Urbana-Champaign
417 Medical Sciences Building, MC-714
506 S. Mathews
Urbana, IL 61801, USA

Office phone: +1 217-265-4036
Lab phone: +1 217-265-5424
Fax: +1 217-265-5290

EDUCATION:

RESEARCH EXPERIENCE/POSTDOCTORAL TRAINING:

  • 1973-1975, Combined B.S.-M.S. Program, Development Biology Department, University of California, Irvine; Irvine, CA (advisor: Gerald Greenhouse, Ph.D.)
  • 1975-1976, Graduate Student, Biology Department, Massachusetts Institute of Technology; Cambridge, MA (advisor: Howard Green, M.D.)
  • 1977-1980, Graduate Student, Biology Department, University of California, San Diego; La Jolla, CA (advisor: William Loomis, Ph.D.)
  • 1980-1981, Postdoctoral Fellow, Biology Department, University of California, San Diego; La Jolla, CA (advisor: William Loomis, Ph.D.)
  • 1982-1983, Postdoctoral Fellow, Biochemistry Department, University of Oxford; Oxford, UK (advisor: Peter Newell, D.Phil.)
  • 1983-1984, Senior Postdoctoral Fellow, Immunology Department, The Scripps Research Institute; La Jolla, CA (advisor: Thomas Edgington, M.D.)

FACULTY POSITIONS:

  • 1984-1989, Assistant Member, Immunology Department, The Scripps Research Institute; La Jolla, CA
  • 1989-1995, Associate Member, Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation (OMRF); Oklahoma City, OK
  • 1991-1997, OMRF Associate Professor of Pathology, University of Oklahoma Health Sciences Center (OUHSC); Oklahoma City, OK
  • 1995-2000, Member, Cardiovascular Biology Research Program, OMRF; Oklahoma City, OK
  • 1997-2000, OMRF Professor of Pathology, OUHSC; Oklahoma City, OK
  • 2000-present, Professor of Biochemistry, University of Illinois College of Medicine at Urbana-Champaign, IL

RESEARCH INTERESTS:

The research in my laboratory is focused on understanding how cells initiate and regulate the blood clotting cascade. The primary event regulating the initiation of clotting in both normal hemostasis and many thrombotic diseases is the exposure of the integral membrane protein, tissue factor (TF), to plasma. This results in the assembly of a two-subunit, membrane-bound enzyme complex consisting of TF (the regulatory subunit) and factor VIIa (a plasma serine protease). The TF:VIIa complex initiates the blood clotting cascade by activating factors IX and X via limited proteolysis. Pathologic TF expression is responsible for the life-threatening coagulopathies associated with sepsis and for the thrombogenicity of atherosclerotic plaques. Thus, the triggering event for myocardial infarction is the rupture or fissure of atheromas, exposing TF directly to the flowing blood and thereby initiating the formation of a thrombus.

Current research projects in the laboratory include analyses of the structure/function relationship of several blood clotting proteases and their protein cofactors, including TF, factor VII and factor X; biophysical studies of the assembly of the TF:VIIa complex on the membrane surface and the role of the membrane in catalysis. As a spinoff from this basic research, we are also working to develop improved diagnostic tests for identifying persons at risk of thrombotic disease, and Improved hemostatic agents to treat bleeding. We have also recently discovered that inorganic polyphosphate, which is secreted by activated platelets, is a potent modulator of blood clotting and fibrinolysis. We are currently investigating the mechanisms by which polyphosphate functions in the blood clotting cascade.

CURRENT GRANT SUPPORT:

  • “Center for Hemostasis Research” (Roy J. Carver Charitable Trust) – grant # 06-2328. Dates: 11-1-05 to 10-31-08, J.H. Morrissey, Principal Investigator.
  • “Mechanisms of Clotting Factor Assembly” (University of Illinois at Urbana-Champaign Research Board) – grant # 06329. Dates: 05/15/06 - 05/31/07, J.H. Morrissey, Principal Investigator.
  • “Mechanisms of Clotting Factor Assembly,” (NHLBI) NIH grant R01 HL47014-14A1. Dates: 12-1-06 to 11-30-11, J.H. Morrissey, Principal Investigator. (Pending)

HONORS, FELLOWSHIPS AND AWARDS:

  • 1981, Young Investigator Award, Society for Developmental Biology
  • 1982-1983, Research Grant, Burroughs-Wellcome Fund (USA)
  • 1982-1983, EMBO Long Term Fellowship
  • 1983, Postdoctoral Fellowship, E.P. Abraham Research Fund
  • 1982-1983, Junior Research Fellowship (nonstipendiary), Wolfson College, Oxford
  • 1988-1993, Established Investigatorship, American Heart Association
  • 1991, The Owren Lecture, University of Oslo, Norway
  • 1992-2000, Fred Jones Distinguished Research Scientist, OMRF
  • 1994, Thelma and Edward L. Gaylord Award for Scientific Excellence, OMRF

PROFESSIONAL AFFILIATIONS:

  • 1987-present, Member, International Society of Thrombosis and Hemostasis (ISTH)
  • 1989-present, Member, American Heart Association (AHA)
  • 1993-present, Member, American Society of Hematology (ASH)
  • 1998-present Member, American Society for Biochemistry and Molecular Biology (ASBMB)

ADVISORY COMMITTEES AND OTHER SERVICE:

  • 1993-1996, Member, Program Committee, AHA Council on Thrombosis
  • 1994-1996, Member, Nominating Committee, AHA Council on Thrombosis
  • 1995-1996, Leader, Tissue Factor Working Group, 6th International Workshop & Conference on Human Leukocyte Differentiation Antigens
  • 1994-1998, Member, Board of Directors, AHA Oklahoma Affiliate
  • 1994-1995, Vice President for Research, AHA Oklahoma Affiliate
  • 1996-1997, President, AHA Oklahoma Affiliate
  • 1997-1998, Vice President of Public Affairs, AHA Oklahoma Affiliate
  • 1998, Member, Board of Directors, AHA Heartland Affiliate
  • 1997-2000, Chair, Endothelial Section, 7th International Workshop & Conference on Human Leucocyte Differentiation Antigens (HLDA7)
  • 2001-2004, Chair, Endothelial Section, 8th International Workshop & Conference on Human Leucocyte Differentiation Antigens (HLDA8)
  • 2000-2003 Member, Executive Committee, AHA Council on Arteriosclerosis, Thrombosis and Vascular Biology
  • 2001, Invited participant, CNS Thrombosis and Hemorrhage Section of the Stroke Progress Review Group for the National Institute of Neurological Disorders and Stroke (NINDS)
  • 2001-2002 Senior Vice Chair, Program Committee, AHA Council on Arteriosclerosis, Thrombosis and Vascular Biology
  • 2004-pres. Member, External Advisory Board, NIH COBRE grant at the Oklahoma Medical Research Foundation
  • 2004-2006, Director, Cell & Molecular Biology Training Grant at the University of Illinois at Urbana-Champagin (funded by NIH)
  • 2005 Invited participant, NIH (NINDS/CSN/NHLBI) Workshop on Immunomodulation Strategies for Preventing Vascular Disease of the Brain and Heart

GRANT REVIEW :

  • NIH Hematology-1 Study Section (ad hoc member): 1993, 1994, 2000
  • NIH Hemostasis & Thrombosis Study Section (ad hoc member): 2004
  • NIH Program Project Grant Review Committees: Many years (most recently: 5/2006)
  • NIH Special Emphasis Panels (fellowships & R01 grants): 1998, 2000, 2002, 2003 (chair), 2005
  • NSF (ad hoc reviewer): 2004
  • Medical Research Council, UK (ad hoc reviewer): 1993
  • VA Medical Research Service (ad hoc reviewer): Many years (most recently: 2/2002)
  • Thrombosis Study Group, American Heart Association (National): Member, 1996-1999, 2002;
    Chair, 2003-2004
  • Clive and Vera Ramaciotti Foundations, Sydney, Australia (ad hoc reviewer): 2002
  • Telethon Foundation (Fondazione Telethon), Rome, Italy (ad hoc reviewer): 2001, 2002, 2003, 2005, 2006
  • Canadian Blood Services Intramural Grants Competition (ad hoc reviewer): 2002, 2003, 2005
  • Member, University of Illinois at Urbana-Champaign Research Board (an intramural study section that reviews institutional grant applications), 2004-present

EDITORIAL BOARDS: